Induced pluripotent stem (iPS) cells from human fetal stem cells
نویسندگان
چکیده
منابع مشابه
Induced Pluripotent Stem Cells: Challenges and Opportunities
Regenerative capacity of mammals is limited and can rarely regenerate a specific organ or tissue fully. Due to these limitations, regenerative medicine seeks efficient and safe cell sources for regeneration of damaged tissues and organs or treatment for incurable diseases. Human embryonic stem cells (HESCs) hold two important properties called self renewal and pluripotency. However, the use of ...
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The loss of retinal ganglion cells (RGCs) is the primary pathological change formany retinal degenerative diseases.Althoughthere is currentlynoeffective treatment for this groupofdiseases, cell transplantation to replace lost RGCs holds great potential. However, for the development of cell replacement therapy, better understanding of themolecular details involved in differentiating stemcells in...
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Kidney disease is a growing health issue for modern society,1–3 and there are a number of causes, including prematurity, genetic abnormalities, inflammation, hypertension, and diabetes. Current treatments for ESRD include dialysis and transplantation, but both are expensive, rely on continuous intervention, and are imperfect in their application.4 – 6 Transplantation also suffers from lack of a...
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Human-Induced Pluripotent Stem Cells The ability to reprogram adult mammalian somatic cells to a pluripotent state has proven to be a paradigm shifting discovery. In 2007, this reprogramming technology was translated to the engineering of human-induced pluripotent stem cells (hiPSCs) using skin fibroblasts by both the Yamanaka (transduction of c-Myc, Oct3/4, SOX2, and Klf4) and Thomson (transdu...
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During embryonic development pluripotency is progressively lost irreversibly by cell division, differentiation, migration and organ formation. Terminally differentiated cells do not generate other kinds of cells. Pluripotent stem cells are a great source of varying cell types that are used for tissue regeneration or repair of damaged tissue. The pluripotent stem cells can be derived from inner ...
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ژورنال
عنوان ژورنال: Best Practice & Research Clinical Obstetrics & Gynaecology
سال: 2016
ISSN: 1521-6934
DOI: 10.1016/j.bpobgyn.2015.08.007